1% EGT Ergothioneine In Skin Care Protect DNA From UV Damage
|Place of Origin:||china,guangdong|
|Brand Name:||no brand|
Payment & Shipping Terms:
|Minimum Order Quantity:||1kg|
|Packaging Details:||1kg or 500g in a bottle, 9 bottle in a carton|
|Product Name:||Ergothioneine In Skin Care||CAS NO:||497-30-3|
|Appearance:||White Crystal||Application:||Cosmetic Raw Materials|
|Storage:||Cool And Dry Place, Long-term Preservation Recommended - 20 ℃||Production Method:||Microbial Fermentation|
|MOQ:||1kg||Product Content:||99% Mannitol And 1% Ergothioneine|
1% Ergothioneine In Skin Care,
EGT Ergothioneine In Skin Care,
Protect DNA From UV Damage Purity 1% EGT Ergothioneine In Skin Care
Ergothioneine (ET) is an unusual sulfur-containing derivative of the amino acid, histidine, which is derived exclusively through the diet. Although ET was isolated a century ago, its physiologic function has not been clearly established. Recently, a highly specific transporter for ET (ETT) was identified in mammalian tissues, which explains abundant tissue levels of ET and implies a physiologic role. Using RNA interference, we depleted cells of its transporter. Cells lacking ETT are more susceptible to oxidative stress, resulting in increased mitochondrial DNA damage, protein oxidation and lipid peroxidation. ETT is concentrated in mitochondria, suggesting a specific role in protecting mitochondrial components such as DNA from oxidative damage associated with mitochondrial generation of superoxide. In combating cytotoxic effects of pyrogallol, a known superoxide generator, ET is as potent as glutathione. Because of its dietary origin and the toxicity associated with its depletion, ET may represent a new vitamin whose physiologic roles include antioxidant cytoprotection.
Sources of Ergothioneine(EGT)
EGT can not be synthesized by human body,it can only be taken from diet.
In 1909, it was isolated from Claviceps purpurea, a fungus parasitic on rye; Then it was found that Actinobacteria, methyl bacillus, some fungi and cyanobacteria could synthesize EGT, but the content of EGT in large fungus mushroom was the highest, reaching 7 mg / g (dw);EGT can't be synthesized by plants and animals. Plants get EGT through root absorption or symbiosis with fungi, while animals get EGT from food;
Efficacy of Ergothioneine(EGT)
1. Strong antioxidant capacity, can effectively eliminate a variety of free radicals
2. Accelerating lipid oxidation
3. Protect mitochondria from damage
4. Resistance to ozone damage to cell
5. Protect DNA from UV-A damage
6. Inhibit the expression of TNF α and MMP-1 to prevent photoaging
7. Anti aging and prevention of various diseases
8. Works as cell preservation
Ergothioneine(EGT) Finished product inspection report
|Product name||ERGO100||CSA NO||497-30-3|
|Produce date||04.01.2021||batch number||20210401|
|Test date||04.25.2021||Shelf life||1 year|
|Test based on||China Food and Drug Administration "Cosmetics Safety Technical Specifications" 2015 edition|
|Test Item||Test standard||Test result|
|Properties||white solid powder||white solid powder|
|Identify||HPLC identification is consistent with the standard product||HPLC identification is consistent with the standard product|
|Total number of colonies (CFU/g or CFU/ml)||500||500|
|Total number of molds and yeasts (CFU/g or CFU/ml)||100||100|
|Thermostable coliforms/g (or ml)||Must not be checked out||not detected|
|Staphylococcus aureus/g (or ml)||Must not be checked out||not detected|
|Pseudomonas aeruginosa/g (or ml)||Must not be checked out||not detected|
|Ergothioneine content (HPLC test)||0.9%-1.1%||0.94%|
1.Skin care: anti-freckle, anti-wrinkle, anti-ultraviolet
Anti-aging, prevent various diseases (improve lung damage And lung inflammation, reduce the risk of cardiovascular disease, Inhibit endothelial cell senescence caused by hyperglycemia)
4. Medical treatment: Organ storage fluid, antioxidant drugs, eye drops
Safe and reliable
On 13 July 2017, the European Commission authorized the introduction of L-ergothioneine as a new food ingredient.In the winter of the same year, the European Food Safety Authority (EFSA) issued a document endorsing the safety of synthetic L-ergothione as a new source of food for the diets of infants, pregnant and lactating women.
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