Cell protection Cosmetic Raw material CAS NO 96702 - 03 - 3 Ectoin
|Small cyclic amino acid derivatives
|dry place, at room temperature
|PH(2% solution in water):
|Cosmetic raw material
|Medicine & Cosmetic
Ectoin is a natural compound found in several species of bacteria. It is a compatible solute which serves as a protective substance by acting as an osmolyte and thus helps organisms survive extreme osmotic stress. Ectoin is found in high concentrations in halophilic microorganisms and confers resistance towards salt and temperature stress. Ectoine was first identified in the microorganism Ectothiorhodospira halochloris, but has since been found in a wide range of Gram-negative and Gram-positive bacteria.
Ectoin is used as an active ingredient in skin care and sun protection products. It stabilizes proteins and other cellular structures and protects the skin from stresses like UV irradiation and dryness.
1.Cellular protection and boosting of skin’s self-defense (in vivo)
2.Global Anti-pollution efficacy (in vivo)
3.Prevention of UV-induced skin damage (in vivo)
4.Wrinkle improvement (in vivo)
5.Long-term hydration – up to 7 days (in vivo)
6.Improvement of skin roughness and scaling (in vivo)
7.Skin barrier repair and reinforcement (in vivo)
8.Inflammation reduction and anti-irritant (in vivo)
9.UVA / UVB, IR-A and visible light protection on cellular level
1 Ectoin's thermal environment protection for cells
Compared with untreated keratinocytes, keratinocytes treated with 1% Ectoin increased their response speed to heat stress and the expression speed of heat shock protein hsp72/73 after heat shock at 44 ℃. 2-3 times
2 Protect cell membranes from surfactant damage
Experiments show that compared with lecithin, Ectoin has a better protective effect on cell membranes, significantly improves the stability of cell membranes under different surfactant pressures, and prevents red blood cell lysis
3 Protection of tetrahydromethylpyrimidine carboxylic acid on cells in 75% ethanol
Use histamine for 1 min Use histamine for 5 min
Apply 1% Ectoin solution to the right arm for pretreatment. After 1 minute, spray 5% histamine phosphate solution on the left and right arms. It is obvious that Ectoin has good cell protection and prevents histamine from causing damage. Redness and itching.
4.Cell protection of Ecotin in 75% ethanol
75% ethanol has an obvious killing effect on viruses and bacteria, and can dissolve the essential phospholipids of virus cell membranes, destroy the integrity of the virus, and achieve the purpose of killing bacteria and viruses. 75% of ethanol is similar to the osmotic pressure of bacteria, which can gradually and continuously penetrate into the bacteria before the surface protein of the bacteria is denatured, so that all the bacteria's protein is dehydrated, denatured and solidified, and finally kills the bacteria.
However, the cell membrane of human skin cells is a layer of phospholipids like viruses, so alcohol kills viruses while destroying our skin cells. Often rubbing the skin with 75% alcohol will cause the following damage:
1. Alcohol has super penetrating power and can penetrate into the cell body. It is the coagulation and denaturation of protein, which makes the cells dehydrated, and the skin will gradually lose its elasticity.
2. Alcohol has high volatility. It also takes away the skin's moisture while taking away the skin's heat, which reduces the skin's natural moisturizing ability and immunity, resulting in dry and rough skin, strong sebum secretion, and large pores. The skin will age faster.
3. After the cosmetics containing alcohol are applied to the skin, a photosensitivity reaction will occur, which will result in aggravation of skin pigmentation and produce spots that are difficult to reverse.
4. Alcohol can paralyze cells, making it difficult for cells to distinguish between the advantages and disadvantages of nutrients, which will absorb some harmful substances to the skin, such as lead, mercury and other harmful substances, making the skin no longer healthy.
These are the hands of a female nurse in the infection department
In 2020, the new type of coronavirus is raging around the world. People all over the world know that 75% of alcohol can be sterilized, but they have neglected the damage caused by long-term use of alcohol to disinfect the skin.
A 22-year-old nurse in the infection department is busy every day in the isolation ward of the hospital. Rubber gloves are disinfected with 75% alcohol, and the hand sanitizer is repeatedly corroded, causing serious damage to the skin of his hands.
75% ethanol is very harmful to cells. After adding ethanol for 1 min, most of the cell membranes of red blood cells (saline has been added) are lysed, and proteins are coagulated due to the dehydration and coagulation of ethanol, as shown in Figure 2, almost no complete cell morphology can be observed.
Pretreatment of red blood cells with 1% Ecotin, add 75% ethanol and let stand for 1 min. It can be seen that a small number of cells are ruptured and dissolved, and most of the cells can be observed intact cell membrane structure. The barrier protection of tetrahydropyrimidine to cells makes ethanol unable It touches and dissolves cell membranes, and because tetrahydropyrimidine also has an excellent protective effect on proteins, a large amount of protein denaturation as shown in Figure 2 did not occur.
Anti-allergic, redness 1%-2%
Sun protection, post-sun repair 0.5%-1%
Skin barrier repair 1%
Basic moisturizing (mask) 0.05%-0.1%
Whitening, anti-aging, freckle removal and other functional products are compounded with 0.3%-0.5%
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